About OBJ
OBJ uses physical science rather than chemistry to provide new levels of product performance
Systemic Transdermal
Local Transdermal
Dermatological
Skincare
Cosmetics
Oral Health
Haircare
Surface Hygiene
Fabric care

Indicator film shows the complexity of micro-array fields needed to mobilise complex molecules such as Peptides

OBJ’s proprietary magnetic fields and magnetic micro-arrays  provide a low cost, powerful  and chemistry-free method of enhancing drug delivery and product performance.

By utilising the natural reluctance of  molecules to move within a magnet field and the energy generated by their motion, OBJ is able to influence the movement and penetration of drugs and active ingredients at the molecular level without the need for costly new chemistry.

When a magnetic micro-array is correctly matched to a product’s atomic structure,  the physical properties of the target, and normal consumer behaviour,  it  provides a low cost, powerful  and chemistry-free method of enhancing product performance.  

SCIENCE BEHIND THE TECHNOLOGY

Complex three-dimensional and moving magnetic fields have the ability to repulse certain molecules to enhance diffusion and alter the permeability of biological and non-biological targets.  These properties of magnetic fields result from:

Diamagnetic Repulsion - a property where matter with paired electrons are repulsed by a magnetic field. OBJ harnesses this force to control the rate, depth of penetration and delivery pathway of active ingredients during diffusion and partitioning.

Induced Charge Permeation - a property of the dielectric characteristics of target barriers. OBJ harnesses this property to manipulate transient permeability and to focus active ingredients at  structures where the physics of  micro-fluidic flow influence delivery outcomes.

Energy Redirection - a property of surface charge accumulation. OBJ harnesses this effect to capture the  motion energy of normal usage behaviour to alter surface flow characteristics and penetration in target barriers.

 

Scientific Journal Articles on OBJ Technologies

(Please see Data Library Section for downloadable documents)

Journal of Pharmacy and Pharmacology

  • Benson H. A. E., Krishnan G., Liew Y., Wallace V.P., Edwards J., Enhanced skin permeation and hydration by magnetic field array: preliminary in vitro and in vivo assessment. J Pharm Pharmacol (in press)

Journal of Pharmaceutical Science  2009

  • Krishnan, G.; Edwards, J.; Chen, Y.; Benson, H. A. E., Enhanced skin permeation of naltrexone by pulsed electromagnetic fields in human skin in vitro. J Pharm Sci 2009. DOI 10.1002/jps.22024

Biopolymers 2008

  • Namjoshi, S.; Chen, Y.; Edwards, J.; Benson, H. A. E., Enhanced transdermal delivery of a dipeptide by dermaportation. Biopolymers 2008, 90, (5), 655-62.

Journal of Chromatography

  • Namjoshi, S.; Caccetta, R.; Edwards, J.; Benson, H. A. E., Liquid chromatography assay for 5-aminolevulinic acid: application to in vitro assessment of skin penetration via Dermaportation. J Chromatogr B 2007, 852, (1-2), 49-55.

 

International Presentations and Publications

 

  • Quirk, C.; Wallace, V. P.; Krishnan, G.; Benson, H. A. E., Magnetic enhanced transdermal drug delivery: in vitro and in vivo efficacy and mechanistic studies In Perspectives in Percutaneous Penetration Conference, La Grande Motte, France, 2010.
  • Namjoshi, S.; Chen, Y.; Edwards, J.; Benson, H. A. E., Electromagnetophoresis: potential for enhanced skin penetration of peptides. In Skin & Formulation 3rd Symposium and Skin Forum 10th Conference, Versailles, France, 2009.
  • Krishnan, G.; Wallace, V.; Edwards, J.; Benson, H. A. E., Electromagnetic field energy as a skin penetration enhancer: preliminary in vitro and in vivo assessment of skin permeation and hydration. In Controlled Release Society and Australasian Pharmaceutical Science Association Conference, Hobart, Tasmania, 2009.
  • Benson, H. A. E.; Edwards, J.; Krishnan, G.; Namjoshi, S., Electromagnetophoresis: potential for enhanced skin penetration of drugs and cosmetics In Skin & Formulation 3rd Symposium and Skin Forum 10th Conference, Versailles, France, 2009.
  • Benson, H. A. E.; Namjoshi, S.; Chen, Y.; Edwards, J., Enhanced transdermal delivery of a dipeptide by inductive energy. In Perspectives in Percutaneous Penetration Conference, La Grande Motte, France, 2008.
  • Namjoshi, S.; Benson, H.; Chen, Y.; Edwards, J. Enhanced transdermal delivery of a dipeptide by Dermaportation, 4th International Peptide Symposium, Cairns, Qld, 2007; Cairns, Qld, 2007.
  • Caccetta, R.; Eijkenboom, M.; Edwards, J.; Namjoshi, S.; Benson, H. A. E. Increased transdermal delivery of local anaesthetics by the novel penetration enhancement technology Dermaportation; in vitro and in vivo assessment, Pharmaceutical Science World Congress, Amsterdam, 2007; Amsterdam, 2007.
  • Benson, H.; Caccetta, R.; Eijkenboom, M.; Edwards, J. Dermaportation treated skin is more permeable to Voltaren Emulgel, World Congress on Inflammation, Copenhagen, 2007; Copenhagen, 2007.
  • Krishnan, G.; Caccetta, R.; Benson, H. A. E.; Edwards, J. Enhanced transdermal delivery of estradiol by Dermaportation, Australasian Pharmaceutical Science Association Annual Conference, Adelaide, 2006; Adelaide, 2006.
  • Benson, H. A. E.; Krishnan, G.; Caccetta, R.; Edwards, J. Dermaportation, a novel skin penetration enhancement technoloy: preliminary investigations with naltrexone, 10th Perspectives in Percutaneous Penetration Conference, La Grande Motte, France, 2006; La Grande Motte, France, 2006.
  • Benson, H. A. E.; Namjoshi, S.; Edwards, J., Dermal penetration enhancement by Dermaportation – Preliminary investigations of a novel technology. J Invest Dermatol 2005, 125, (6), A12.
  • Benson, H. A. E.; Namjoshi, S.; Edwards, J. Dermal delivery enhancement by Dermaportation – a novel penetration enhancement technology, 39th Annual Conference of the Australian Society of Cosmetic Chemists, Brisbane, 2005; Brisbane, 2005.
  • Benson, H. A. E.; Caccetta, R.; Namjoshi, S.; Edwards, J.; Eijkenboom, M. Rapid delivery of local anaesthetics by Dermaportation – a novel skin penetration enhencement technology, World Congress on Pain, Sydney, 2005; Sydney, 2005.
  • Namjoshi, S.; Caccetta, R.; Edwards, J.; Benson, H. A. E. Enhancement of skin penetration by Dermaportation, Australasian Pharmaceutical Science Association Annual Conference, Melbourne, 2004; Melbourne, 2004.