Skin penetration enhancement of the local anaesthetic Tetracaine – a placebo controlled blinded clinical study.

A pilot study by Curtin University to investigate the skin penetration enhancement of Dermaportation in vivo using loss of sensation due to tetracaine local anaesthetic gel as a pharmacodynamic measure of skin penetration in healthy volunteers. Results were based on data from 5 healthy volunteers, each using two active and two passive Dermaportation patch applicators

CONCLUSION:

Dermaportation decreased the time to onset of tetracaine with a clear difference in all volunteers at 15 min post administration (von Frey data). This provides preliminary evidence of the in vivo skin penetration enhancement effect of the Dermaportation technology in healthy volunteer subjects.

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TETRACAINE HYDROCHLORIDE

- Molecular Formula: C₁₅H₂₄N₂O₂ HCl

- Molecular Weight: 300.83

- Local surface, conduction and infiltration anaesthetic or contact anaesthetic of the benzoate ester-type. Its main place of action is the neuronal membrane where it acts on neurones by limiting the process of excitation and conduction.